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We conclude that,since the gene for PreA4 is on the long arm of chromosome 21,which is present in triplicate in Down's syndrome,overexpression of this gene may lead to increased levels of PreA4 and amyloid deposition in Down's syndrome.However,since increased levels of PReA4 are not present in Alzheimer's disease,additional factors must account for the amyloid deposition in that disorder. |
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